Combined Neurometabolic Therapy in Various Clinical Forms of Tic Hyperkinesis in Children: Effects on Motor and Non-Motor Symptoms

Tic hyperkinesis is one of the most common forms of extrapyramidal pathology in childhood. Recently, interest in non-motor manifestations of tic hyperkinesis in children has increased, as they include ADHD, OCD and anxiety disorder. It is assumed that all these neuropsychiatric diseases have a single pathophysiological basis. However, the question of effective therapy of these comorbid disorders accompanying tic hyperkinesis in children still remains. Aim: to im-prove the quality of inpatient medical care in military hospitals and increase patient satisfaction with medical services . Materials and methods: the study involved 167 patients (193 boys and 74 girls) with tic hyperkinesis aged 6 to 12 years (mean age 8.2 ± 2.3 years). All patients were divided into four groups depending on the clinical course of the disease: Group I: 32 patients with transient tics; Group II: 120 patients with chronic tics. Group III: 15 patients with Gilles de la Tourette syndrome. Motor symptoms were assessed using the YGTSS scale, and non-motor symptoms were assessed using standardized scales: Y-BOCS, SNAP-IV and STAI. The severity of symptoms was assessed before and after treatment. Results: combination neuropharmacotherapy was effective in reducing the severity of tics, ADHD, OCD, and anxiety disorder symptoms in all clinical forms of tic hyperkinesis in children. In addition, combination therapy statistically significantly reduced the severity of tics in patients with Gilles de la Tourette syndrome, ADHD symptoms in patients with transient tics and Gilles de la Tourette syndrome, and OCD symptoms in patients with Gilles de la Tourette syndrome compared to monotherapy. Conclusion: the results of this study showed that combination therapy with hopantenic acid in combination with the main line of therapy in children with tic hyperkinesis is effective in treating both tics themselves and symptoms of ADHD, OCD, and anxiety disorder.

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