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ANALYSIS OF CTLA-4 GENE POLYMORPHISMS IN TYPE 1 DIABETES MELLITUS

Saidov, Zukhriddin Usmonali ugliJizzakh Branch of the National University of UzbekistanErgasheva, Elnura Tokhir qiziJizzakh Branch of the National University of UzbekistanSagdullayeva, Iroda Normakhamat qiziJizzakh Branch of the National University of UzbekistanSaidova, Makhliyo Usmonali qiziAndijan State UniversityMustafakulov, Muhammadjon AbduvaliyevichInstitute of Biophysics and Biochemistry

Zenodo (CERN European Organization for Nuclear Research)repository2025

ABI

Annotatsiya

Type 1 Diabetes (T1D) is a chronic autoimmune disease that results from the destruction of insulin-producing pancreatic β-cells by the body's own immune system. The development of the disease is significantly influenced by both genetic and environmental factors. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) plays a critical regulatory role in the immune system and serves as a decisive factor in the pathogenesis of T1D. This article analyzes the impact of CTLA-4 gene polymorphisms on the development of T1D. The purpose of this article is to provide a comprehensive analysis of the role and clinical significance of CTLA-4 gene polymorphisms in the pathogenesis of Type 1 Diabetes, as well as to study the characteristics of this association across different ethnic groups.

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Mavzular

Diabetes and associated disorders Pancreatic function and diabetes Diabetes Management and Research

Identifikatorlar

DOI: 10.5281/zenodo.17539668

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