PERIODONTITIS AS A MANIFESTATION OF SYSTEMIC DISEASE

Chronic periodontitis is a multifactorial inflammatory disease characterized by progressive destruction of periodontal tissues and alveolar bone. While microbial biofilm initiates the inflammatory process, individual variability in disease progression suggests a significant contribution of host-related factors, particularly genetic determinants of immune response. Pro-inflammatory cytokines play a key role in regulating periodontal inflammation, and genetic polymorphisms affecting cytokine expression may influence disease severity and clinical outcomes.

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