The Influence Of Chemical Factors On The Synthesis Of Amino Acids And The Production Of Biologically Active Substances Based On Them
Annotatsiya
In the article formation of aminoalcohols and aminocompounds by Mannich reaction from acetylenic alcohols and phenylacetylene and also biological activity of halogenated derivatives of the synthesized aminocompounds have been inves -tigated. Acetylenic alcohols were synthesized by the reaction A.E. Favorsky and phenylacetylene was obtained from styrene. The influence of various factors (tem -perature, catalyst, time and nature of solvents) on the yield of aminoalcohols was studied. A theoretical analysis of the mechanism of formation of acetylenic amino- alcohols is given. The physico-chemical properties of the synthesized aminoalcohols and their yields were determined. The chemical structure of aminoalcohols has been confirmed by IR and PMR spectrums. The biological activity of compounds syn-thesized by chlorination and bromination of aminocompounds has been investigated.
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