PECULIARITIES OF PSYCHOPATHOLOGICAL AND NEUROPSYCHOLOGICAL FEATURES OF NEGATIVE SYMPTOMS IN LATE-LIFE SCHIZOPHRENIA

PECULIARITIES OF PSYCHOPATHOLOGICAL AND NEUROPSYCHOLOGICAL FEATURES OF NEGATIVE SYMPTOMS IN LATE-LIFE SCHIZOPHRENIA Ochilov Ulug’bek Usmanovich [email protected] DSc, Associate Professor of the department of psychiatry and narcology, Samarkand State Medical University, Uzbekistan, Samarkand city, Amir Temur street 18, Tel: +998 66 2330841 E-mail: [email protected]. Shaimov Doston Oqbo’ta o’g’li [email protected] Ismoilov Bolbek Saymamatovich [email protected] Xidirov Muhammadsodiq Yunus o’gli [email protected] Clinical Resident, Psychiatry and Narcology Course, Samarkand State Medical University, Uzbekistan, Samarkand city, Amir Temur street 18, Tel: +998 66 2330841 E-mail: [email protected]. https://doi.org/10.5281/zenodo.18241925 ANNOTATION: Relevance. Late-onset schizophrenia often manifests as a slow-progressing form, which delays diagnosis by 10–15 years from its initial stage. Slow schizophrenia is characterized by borderline pathologies, which are often not recognized as symptoms of illness by patients and their relatives, and do not prompt seeking medical care. Additionally, affective (depressive) disorders and high rates of psychoactive substance dependence are frequently observed in slow schizophrenia. Objective. The study aimed to identify the features of higher mental function impairments in patients with late-onset schizophrenia. Materials and Methods. A total of 76 patients (48 women and 28 men), aged 46-68 years (mean 52±5,8), with schizophrenia debuting in late adulthood, were examined. The duration of illness in the main group ranged from 1 to 21 years (mean 7,3±6,12), while the control group (aged 32–59 years) had illness duration from 0.5 to 21 years (mean 7,8±6,7). Clinical-psychopathological, pathopsychological, and neuropsychological methods were applied. Results. An apatho-abulic defect was identified in 38,2% of the main group, and a pseudo-organic defect in 29% of patients. Late-onset schizophrenia patients showed significant deficits in speech, memory, praxis, and thinking compared to the control group (p<0,05). Psychocognitive defects varied in type, with apatho-abulic and pseudo-organic variants corresponding to distinct neuropsychological syndromes. Slow schizophrenia also commonly involves a combination of affective, psychopathic-like, and neurocognitive disturbances. Conclusion. The study demonstrated that defect types in late-onset schizophrenia are pathogenetically interconnected and indicate progressive impairments in higher mental functions. The findings allow for localized neurocognitive diagnostics and provide critical guidance for individualized psycho-rehabilitation, including the development of cognitive and social skills. Keywords: late-onset schizophrenia, slow-progressing schizophrenia, neuropsychological deficit, apatho-abulic defect, pseudo-organic defect, higher mental functions.

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