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Non-coding RNAs as key players in neurodegeneration and brain tumors: Insights into therapeutic strategies.

Mohamed J. SaadhFaculty of Pharmacy, Middle East University, Amman, 11831, JordanSarraa Ahmad QahtanDepartment of Anesthesia Techniques, Health and Medical Techniques College, Alnoor University, Mosul, IraqRafid Jihad AlbadrAhl al Bayt University, Karbala, IraqGaurav SanghviMarwadi University Research Center, Department of Microbiology, Faculty of Science, Marwadi University, Rajkot-360003, Gujarat, IndiaR. RoopashreeDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, IndiaAditya KashyapCentre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, IndiaA. SabarivaniDepartment of Biomedical, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, IndiaJasur RizaevDepartment of Public Health and Healthcare Management, Rector, Samarkand State Medical University, 18, Amir Temur Street, Samarkand, UzbekistanWaam Mohammed TaherCollege of Nursing, National University of Science and Technology, Dhi Qar, IraqMariem AlwanPharmacy college, Al-Farahidi University, IraqMahmod Jasem JawadDepartment of Pharmacy, Al-Zahrawi University College, Karbala, IraqAli M. Ali Al-Nuaimi

PubMedrepository2025en

ABI

Annotatsiya

Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and other ncRNA types, have emerged as key regulators in neurodegenerative diseases and brain tumors. This review aims to provide insights into the role of ncRNAs in these conditions and their potential as diagnostic and therapeutic targets. We systematically reviewed literature from databases such as PubMed, Scopus, and Web of Science, applying specific inclusion and exclusion criteria to ensure comprehensive coverage of recent advancements. Although ncRNAs are involved in a range of molecular pathways, challenges in clinical translation, including specificity, cost, and validation, persist. This review highlights innovative strategies to overcome these barriers and promote the clinical application of ncRNAs. Moreover, we explore the emerging role of extracellular vesicle-enriched ncRNAs as cell-free therapeutic options for neurodegenerative diseases. The findings presented here emphasize the need for robust validation and the development of specific ncRNA-based treatments.

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Mavzular

Circular RNAs in diseases MicroRNA in disease regulation Cancer-related molecular mechanisms research

Identifikatorlar

DOI: 10.22038/ijbms.2025.85350.18446

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