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Impact of Bone Growth Stimulants on Bone Regeneration in Dental Implantology: A Meta-Analysis

Niladri MaitiCentral Asian University, School of Dentistry, Tashkent 111221, UzbekistanRiddhi ChawlaCentral Asian University, School of Dentistry, Tashkent 111221, UzbekistanAhmad Danish RehanProfessor and Head, Oral Pathology and Microbiology and Forensic Odontology Department of Dentistry, Zoram Medical College, Falkawn, Mizoram 796005, IndiaAtaul Hafeez ImranBDS, MDS (Conservative Dentistry and Endodontics), FICOI (USA), Fellowship in Laser Dentistry (WCLI, USA), Private Practitioner, Noor Hospital, Qadian, District Gurdaspur, Punjab 143516, IndiaJaiganesh RamamurthyProfessor, Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai 600077, IndiaShipha HegdeDepartment of Prosthodontics, Crown & Bridge, A.B. Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Mangaluru 575018, Karnataka, India

Bangladesh Journal of Medical Sciencejournal2026

ABI

Annotatsiya

Bone growth stimulants (BGS) are increasingly used to enhance osseointegration in dental implants, but their efficacy remains debated. This meta-analysis evaluates the impact of BGS on bone regeneration and implant success. Following PRISMA guidelines, 25 studies (2000–2024) were analyzed. Random-effects models pooled effect sizes for outcomes like bone density and implant survival. Subgroup analyses compared graft types (autografts, alloplastics, bio-enhanced grafts). BGS improved osseointegration (pooled ES: 1.22, 95% CI: 0.95– 1.50), with bio-enhanced grafts showing the highest efficacy (ES: 1.43). Bioactive coatings (ES: 1.26) outperformed strontium coatings (ES: 0.94), while bisphosphonates negatively impacted outcomes (ES: -1.96). Heterogeneity was low (I² = 9.08%), but publication bias was detected (Egger’s test: *p* = 0.025). BGS, especially combination grafts, enhance implant stability, though patient-specific factors must guide clinical use. Bangladesh Journal of Medical Science Vol. 25. Supplementary Issue 2026, Page : S36-S49

Mavzular

Dental Implant Techniques and Outcomes Periodontal Regeneration and Treatments Bone Tissue Engineering Materials

Identifikatorlar

DOI: 10.3329/bjms.v25i10.86621

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