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Plasma-activated hydrosol and graphene oxide nanoparticles exhibit synergistic anticancer effects

Zewei WangFrontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, People’s Republic of ChinaDanqi ZhangSchool of Life Sciences and Technology, Xi’an Jiaotong University, Xi’an 710049, People’s Republic of ChinaXixi JingState Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, People’s Republic of ChinaZimu YuFrontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, People’s Republic of ChinaJishen ZhangState Key Laboratory of Electrical Insulation and Power Equipment, Centre for Plasma Biomedicine, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, People’s Republic of ChinaZifeng WangFrontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, People’s Republic of ChinaHao ZhangDepartment of Physics, Department of Materials Science and Engineering, and Department of Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong Special Administrative Region of China, People’s Republic of ChinaMaksudbek YusupovDepartment of Digital Electronics and Microelectronics, Tashkent State Technical University, Universitet 2, 100095 Tashkent, UzbekistanO. A. KovalInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Akad. Lavrentiev Ave. 8, Novosibirsk 630090, RussiaJamoliddin RazzokovInstitute of Fundamental and Applied Research, National Research University TIIAME, Kori Niyoziy 39, 100000 Tashkent, UzbekistanDingxin LiuInterdisciplinary Research Center of Frontier science and technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, People’s Republic of China

Journal of Physics D Applied Physicsjournal2026

ABI

Annotatsiya

Abstract Cold atmospheric plasma-activated hydrosol (PAH) is a novel plasma application mode for the effective loading and delivery of plasma-generated reactive oxygen/nitrogen species (RONS). In this study, plasma-activated sodium alginate hydrosol (PAH SA ) was obtained from air discharge plasma, and the synergistic anticancer effects of PAH SA combined with graphene oxide nanoparticles (GO) were investigated. The results demonstrated that the oxidation-reduction potential of PAH SA increased significantly after long-lived and short-lived plasma-generated RONS, such as H 2 O 2 , NO 2 −, 1 O 2 , and ONOO − &O 2 − , were loaded. In vitro studies revealed that PAH SA exhibited significant anticancer effects by inducing intracellular oxidative stress. While B16F10 cell viability tended to decrease with increasing GO concentration, only at high concentrations did GO significantly inhibit tumor cell proliferation. In addition, when PAH SA was combined with low-dose GO (0.5 mg ml −1 ), the proliferation of B16F10 melanoma cells was significantly inhibited compared with treatment with PAH SA or GO alone at the same dose. These findings indicate that PAH SA can be combined with novel materials, thus expanding the application of plasma technology for anticancer therapy and providing new cancer treatment strategies.

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Mavzular

Plasma Applications and Diagnostics Surface Modification and Superhydrophobicity Medical and Biological Ozone Research

Identifikatorlar

DOI: 10.1088/1361-6463/ae383b

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