Therapeutic effects of wogonin on sepsis and its mechanisms of action: a comprehensive systematic review
Husni FarahFaculty of Allied Medical Sciences, Hourani Center for Applied Scientific Research, Al-Ahliyya Amman UniversityWaleed K. AbdulsahibDepartment of Pharmacology and Toxicology, College of Pharmacy, Al Farahidi UniversityIhsan Khudhair JasimDepartment of Pharmaceutics, Faculty of Pharmacy, Al-Turath UniversitySoumya V. MenonDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University)Pradeepta Sekhar PatroDepartment of Immunology, IMS and SUM Hospital, Siksha ‘O’ AnusandhanA. SabarivaniDepartment of Biomedical, Sathyabama Institute of Science and TechnologyGunjan MukherjeeUniversity Institute of Biotechnology, Chandigarh UniversityAashna SinhaSchool of Applied and Life Sciences, Division of Research and Innovation, Uttaranchal UniversityJasur RizaevDepartment of Public health and Healthcare management, Rector, Samarkand State Medical University
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studies indicates that wogonin exerts protective effects against sepsis-induced organ damage by modulating critical signalling pathways such as NF-κB, MAPK, and Nrf2/HO-1. Despite these promising findings, further clinical trials are necessary to establish the safety and efficacy of wogonin in human subjects suffering from sepsis.
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