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Unusual case of follicular lymphoma of vocal cord

Griffin H. WillmanCharles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USAZohre SadeghianDepartment of Pathology and Laboratory Medicine, Cleveland Clinic Florida, 2950 Cleveland Clinic Boulevard, Weston, FL, 33331, USAJyotsna KochiyilDepartment of Imaging, Cleveland Clinic Florida, Weston, FL, USAChieh Lin FuDepartment of Hematology and Oncology, Cleveland Clinic Florida, Weston, FL, USASamuel J. TrosmanDepartment of Head and Neck Surgery, Cleveland Clinic Florida, Weston, FL, USAGulrukh BotiralievaNatalya PakCentral Asian University, Tashkent, UzbekistanYaroslav ChernovThe Institute for Urology and Reproductive Health, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, RussiaShukhrat A. AbdukhalikovImpuls Medical Institute Chirchiq Branch, Tashkent, UzbekistanAmir BehdadDepartment of Pathology and Laboratory Medicine, Cleveland Clinic Florida, 2950 Cleveland Clinic Boulevard, Weston, FL, 33331, USAKirill A. LyapichevDepartment of Pathology and Laboratory Medicine, Cleveland Clinic Florida, 2950 Cleveland Clinic Boulevard, Weston, FL, 33331, USA. [email protected]

Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicinjournal2026en

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Annotatsiya

Primary laryngeal lymphoma is a rare diagnosis, accounting for less than 1% of all laryngeal tumors. Approximately 100 cases have been reported in the English-language literature. A variety of lymphoma classifications have been described, including diffuse large B-cell lymphoma, NK/T-cell lymphoma, Burkitt lymphoma, lymphoplasmacytic lymphoma, mucosa-associated lymphoid tissue (MALT) lymphoma, mantle cell lymphoma, marginal zone lymphoma, and peripheral T-cell lymphoma. To our knowledge, follicular lymphoma involving the larynx has been rarely reported. We report a case of a 74-year-old woman who presented with a 1-year history of hoarseness refractory to semi-occluded vocal tract (SOVT) therapy and was diagnosed with follicular lymphoma involving the false vocal fold. At presentation, the patient felt well and did not have any B symptoms. Initial computed tomography (CT) scan of the neck did not show any lesions, but a subsequent videolaryngostroboscopy revealed a small lesion in the false vocal folds. The lesion was surgically excised, and histological evaluation revealed features consistent with a diagnosis of follicular lymphoma. Herein, we present a rare case of primary follicular lymphoma of the larynx and describe its histological and immunophenotypic characteristics. Furthermore, we conducted an extensive review of the English-language literature and discuss comparable published cases.

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Mavzular

Lymphoma Diagnosis and Treatment CNS Lymphoma Diagnosis and Treatment Viral-associated cancers and disorders

Identifikatorlar

DOI: 10.1007/s00428-026-04443-z

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