The Role Of Pancreatic Trypsin Inhibitor (Spink1) Gene Polymorphisms In The Course Of Acute Pancreatitis In The Uzbek Population
Madatov Kurbonboy AminboyevichDepartment of Surgical Diseases, Tashkent State Medical University, UzbekistanIsmailov Uktam SafayevichDepartment of Surgical Diseases, Tashkent State Medical University, UzbekistanSharopov Asliddin NasriddinovichDepartment of Surgical Diseases, Tashkent State Medical University, UzbekistanMatmuratov Seyilkhon KuronboyevichDepartment of Surgical Diseases, Tashkent State Medical University, UzbekistanRakhimov Rasulbek IbrokhimovichDepartment of Surgical Diseases, Tashkent State Medical University, Uzbekistan
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This article examines the results of the influence of the SPINK1 (Asn34Ser) polymorphism on the incidence of acute pancreatitis. Environmental factors, in conjunction with genetic factors, play a crucial role in the mechanism of acute pancreatitis development. It was found that there are ethnic differences in the distribution of allele and genotype frequencies of this gene's polymorphic variant. Further development of molecular genetic research through studying the genetic basis of pancreatitis is important for developing new methods of diagnosis and determining treatment strategies with an individualized approach to each patient.
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