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Modern Perspectives on The Impact of Comorbidities on The Course of Covid-19 In Children

Rakhmatullaeva Shaxnoza BaxadirovnaProfessor of the Department of Infectious Diseases and Pediatric Infectious Diseases, Doctor of Medical Sciences, Tashkent State Medical University, Tashkent, UzbekistanSadullaev Siroj ErnazarovichAssistant at the Department of Infectious Diseases, Epidemiology, and Phthisiology of the Urgench State Medical Institute, Urgench, UzbekistanQurbonov Bunyod ShavkatovichSenior Lecturer at Turon University, Karshi, UzbekistanGullieva Nozima ShavkatovnaTrainee teacher of Turon University Karshi, Uzbekistan
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This article analyzes contemporary scientific literature regarding the impact of comorbidities on the course of COVID-19 in children. Obesity, diabetes mellitus, cardiovascular diseases, chronic lung diseases, neurological disorders, and immunodeficiency states are examined as independent risk factors for a severe course of COVID-19. Pathogenetic mechanisms, including cytokine storm, increased inflammatory markers, and T-cell immunity dysfunction, are described in detail. The article also highlights the clinical significance of MIS-C syndrome, its diagnostic criteria, modern treatment approaches, and vaccination recommendations.

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