Ru–Au nanocluster-functionalized carbon fiber microelectrode enables ultrasensitive multiplexed monitoring of acetaminophen and its genotoxic interplay with DNA
Tao FANGSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, ChinaMin ShiSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, ChinaUchkun ISHIMOVInstitute of Bioorganic Chemistry, Uzbekistan Academy of Sciences, Tashkent, UzbekistanAwais IhsanDepartment of Biosciences, COMSATS University Islamabad Sahiwal Campus, Sahiwal, PakistanJun LiSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, ChinaXianju HuangSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, China
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hydrogen bonding and π-π stacking, providing mechanistic insights into its hepatotoxicity at high concentrations. The proposed sensor not only offers a robust platform for multiplexed drug monitoring but also advances understanding of ACOP-induced DNA damage, highlighting its potential in pharmacokinetic studies and toxicity assessment. This work underscores the significance of nanomaterial-enhanced electrochemical sensors for pharmaceutical quality control and toxicity assessment.
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