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Effects of plant flavonoids and selenium on pancreatic hormones and glucose homeostasis in autoimmune thyroiditis

Khasan KayumovNational University of Uzbekistan named after Mirza UlugbekL.S. KuchkarovaNational University of Uzbekistan named after Mirza UlugbekDilnoza RomanovaNational University of Uzbekistan named after Mirza UlugbekSzczuko MałgorzataDepartment of Bromatology and Diagnostic Nutrition, Pomeranian Medical University in SzczecinSevara BerdiyorovaNational University of Uzbekistan named after Mirza UlugbekNurali ErgashevInstitute Biophysics and Biochemistry at National University of Uzbekistan named after Mirza UlugbekIroda KarimovaNational University of Uzbekistan named after Mirza UlugbekUmida R. YusupovaNational University of Uzbekistan named after Mirza UlugbekGulchehra M.-K. DjabbarovaNational University of Uzbekistan named after Mirza UlugbekSobitjon Oltinovich MirzakulovNational University of Uzbekistan named after Mirza UlugbekAnna BOKOVANational University of Uzbekistan named after Mirza UlugbekNurshat MURTAZAYEVANational University of Uzbekistan named after Mirza UlugbekManzura Adhamovna AgzamovaS. Yu. Yunusov Institute of the Chemistry of Plant Substances Uzbekistan Academy of SciencesK. A. ÉshbakovaS. Yu. Yunusov Institute of the Chemistry of Plant Substances Uzbekistan Academy of SciencesBakhrom KomilovS. Yu. Yunusov Institute of the Chemistry of Plant Substances Uzbekistan Academy of SciencesAziz Mukhtorovich KobilovDepartment of Biotechnology and Food Safety, Bukhara State University

EXPERIMENTAL ANIMALSjournal2026en

ABI

Annotatsiya

Autoimmune thyroiditis (AIT) is a systemic autoimmune disorder that extends beyond thyroid dysfunction and is associated with disturbances in pancreatic endocrine secretion and glucose metabolism. The present study aimed to evaluate the effects of selected plant flavonoids-dihydroquercetin, chrysoeriol, luteolin, resveratrol, kaempferol, and thamiflaside-administered alone or in combination with selenium on pancreatic hormone secretion, glycemic control, and hepatic glycogen content in an experimental rat model of AIT. AIT was induced in male Wistar rats using thyroglobulin and Freund's adjuvant. After confirmation of autoimmune thyroiditis, animals received flavonoid treatment (20 mg/kg body weight), with or without selenium, for 14 days. Serum concentrations of insulin, glucagon, amylin, and somatostatin were determined by immunoassay. Glycated hemoglobin (HbA1c) was measured as an indicator of long-term glycemic control, and hepatic glycogen content was assessed in liver homogenates. AIT induction resulted in marked metabolic dysregulation characterized by reduced insulin and amylin secretion, elevated glucagon levels, impaired somatostatin regulation, increased HbA1c, and depletion of hepatic glycogen stores. Flavonoid treatment produced compound-specific corrective effects. Luteolin and kaempferol, particularly in combination with selenium, showed the strongest efficacy by restoring pancreatic hormone balance, reducing hyperglucagonemia, improving HbA1c levels, and replenishing hepatic glycogen toward physiological ranges. Dihydroquercetin and chrysoeriol exerted moderate protective effects, whereas resveratrol and thamiflaside showed limited efficacy. In conclusion, autoimmune thyroiditis induces significant disturbances in pancreatic endocrine function and hepatic glucose metabolism, while flavonoid-selenium combinations may represent promising strategies for correcting AIT-associated metabolic dysfunctions.

Mavzular

Selenium in Biological Systems Saffron Plant Research Studies Silymarin and Mushroom Poisoning

Identifikatorlar

DOI: 10.1538/expanim.26-0007

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