Integrated plasmonic waveguide sensor for continuous glucose monitoring in diabetic patients of the Fergana Region

Integrated plasmonic waveguide sensors have the potential to deliver continuous, minimally invasive glucose monitoring with high sensitivity, reliability and low power consumption. This study describes the design and clinical evaluation of an integrated plasmonic waveguide sensor tailored for adults with diabetes living in the Fergana Region of Uzbekistan. The device combines a flexible polymeric waveguide, a gold nanostructured sensing surface and a compact optical read-out module embedded in a wearable patch that interrogates interstitial fluid through a microneedle interface. In a prospective study, sensor performance was compared with capillary blood glucose measurements and factory-calibrated continuous glucose monitoring systems during daily life over fourteen days. Primary endpoints included analytical sensitivity, stability of the resonance wavelength, mean absolute relative difference and time in clinically acceptable error grids. The plasmonic waveguide sensor achieved clinically acceptable agreement with reference methods, supporting its potential role as an affordable, regionally manufacturable tool for long-term diabetes self-management.

Hali tarjima qilinmagan