C-reactive protein and antimicrobial peptide LL-37 in patients with psoriasis
Annotatsiya
Relevance: Psoriasis (PS) is a common dermatosis which accounts for 1.2-2.2% of the population and is based on the immune-genetic mechanism of both systemic and local development. Purpose of the research. An assessment of the level of C-reactive protein and antimicrobial peptide LL-37 in the peripheral blood of psoriasis patients, taking into account the PASI score. Material and methods. 56 patients with psoriasis aged 18 to 65 years were examined. All patients underwent clinical (PASI), immunological, microbiological, and statistical studies. Results. The study results have shown that with an increase in the severity of the PASI, an increase in the level of C-reactive protein and the antimicrobial peptide LL-37 in the blood serum is noted against the background of increased colonization of Staphylococcus spp. on the skin in patients with psoriasis. Conclusion. A high level of S. aureus in lesions and a high level of the antimicrobial peptide LL-37 in patients with psoriasis can be considered a trigger factor, and an increase in the level of CRP in the blood serum of patients with psoriasis plays a key role as a marker of systemic inflammation due to the stimulation of the pro-inflammatory systems.