HISTOLOGICAL AND MICROVASCULAR CHANGES IN THE UTERUS UNDER CHRONIC CARBON MONOXIDE EXPOSURE

Resume. Carbon monoxide (CO) is a toxic gas produced during incomplete combustion of carbon-containing materials and is considered one of the major environmental pollutants. Chronic exposure to carbon monoxide can lead to tissue hypoxia and structural alterations in various organs. However, the influence of long-term CO exposure on the microvascular system of the uterus remains poorly understood. The aim of this study was to investigate histological and microvascular changes in uterine tissues under chronic carbon monoxide exposure in experimental animals. The study was conducted on 40 female white laboratory rats divided into control and experimental groups exposed to different concentrations of CO. Histological and morphometric analyses were performed to evaluate structural alterations and vascular changes in uterine tissues. The results revealed significant microvascular dilation, increased vascular density, and degenerative changes in endometrial structures under chronic CO exposure. These findings suggest that prolonged exposure to carbon monoxide leads to significant alterations in uterine microcirculation and tissue organization, which may adversely affect reproductive function. Keywords: carbon monoxide, uterus, morphology, hypoxia, experimental study

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