Prevalence of Hemorrhoidal Disease in Patients with Non-Alcoholic Fatty Liver Disease: Immunological Risk Factors and Pathophysiological Mechanisms
Annotatsiya
Non-alcoholic fatty liver disease (NAFLD) affects nearly one-third of adults worldwide and has become a major public health concern. Hemorrhoidal disease is another common condition that significantly affects quality of life. Although both disorders involve chronic inflammation and metabolic disturbances, their potential relationship has received little attention in the literature. The present study aimed to review the prevalence of hemorrhoidal disease among NAFLD patients and explore the immunological mechanisms that might link these conditions. In this study searched PubMed, Scopus, Web of Science, and Cochrane Library for relevant studies published between 2010 and 2024 using terms related to NAFLD, hemorrhoids, inflammation, and portal hypertension. NAFLD patients showed higher hemorrhoid prevalence than the general population. Key factors included elevated inflammatory cytokines (TNF-α, IL-6, IL-1β), gut-liver axis disruption, and subclinical portal hypertension. NAFLD and hemorrhoidal disease share common inflammatory pathways. Recognizing this link may help clinicians provide better care for patients with both conditions.