The microbial metabolome: remodeling the therapeutic landscape in hematologic malignancies
Liang ZhangGanzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, China. [email protected]Hamed Soleimani SamarkhazanStudent Research Committee, Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. [email protected]Yaseer almajidiDepartment of medicine, Tehran university, Tehran, IranRushen GafarovDepartment of Urology, Samarkand State Medical University, Samarkand, Uzbekistan
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The gut microbiome's metabolome critically shapes drug efficacy and toxicity in hematologic malignancies. This review explores how microbial metabolites influence chemotherapy, immunotherapy, and transplant outcomes, and how they can be harnessed as biomarkers and therapeutic targets. Moving from association to intervention, we outline a pathway toward metabolome-informed precision oncology, transforming the "second genome" into a actionable ally for improved cancer therapy.
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