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RETICULOCYTE SUBPOPULATION ANALYSIS AND ITS CORRELATION WITH IRON DEFICIENCY ANEMIA: A RETROSPECTIVE STUDY IN A PREDOMINANTLY FEMALE POPULATION.

M Madi1Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, UAE; 2Burjeel Royal Hospital, Al Ain, Abu Dhabi, United Arab EmiratesH Awad2Burjeel Royal Hospital, Al Ain, Abu Dhabi, United Arab EmiratesM Ismail1Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, UAEM Butaboyev3Department of Rehabilitology, Sports Medicine, Traditional Medicine and Physical Education, Andijan State Medical Institute, UzbekistanJ Bobokalonzoda4Department of Botany and Dendrology, Faculty of Biology, Tajik National University, Dushanbe, TajikistanA Gaybiev5Department of Neurology, Samarkand State Medical University, UzbekistanE Ali6Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Northern Border University, Arar, Saudi ArabiaH Elzein6Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Northern Border University, Arar, Saudi ArabiaR Babiker7Department of Physiology, RAK College of Medical Sciences, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates; 8Department of Physiology, Faculty of Medicine and Surgery, National University - Sudan (NUSU), Khartoum, SudanA Banaga9Department of Internal Medicine, Faculty of Medicine and Surgery, National University-Sudan (NUSU)S Hussein1Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, UAEA Alfeel1Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, UAEA Osman1Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, UAEA Babker1Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, UAE

PubMedrepository2026en

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Annotatsiya

BACKGROUND: Serum ferritin and iron have high inter-individual variability and inflammatory sensitivity, limiting its diagnostic value in several clinical settings. The Reticulocyte Subpopulation Analysis may indicate iron availability during erythropoiesis in real time. AIM: This study investigated the associations between reticulocyte parameters and various hematological and iron-related biomarkers in Iron Deficiency Anemia. METHODS: In this retrospective study, 150 patients with IDA (Iron Deficiency Anemia) were included (146 females, 97.3%; 23 pregnant, 15.8%; 12 on iron treatment, 8.0%), RET-He, LFR/MFR/HFR, and IRF were correlated with iron markers. Associations between anemia severity and treatment status were examined using Spearman correlation, Kruskal-Wallis, and Mann-Whitney U analyses. RESULTS: While other reticulocyte indices exhibited minor connections, RET-He showed strong positive correlations with ferritin (r=0.430, p<0.001), serum iron (r=0.364, p<0.001), and transferrin saturation (r=0.350, p<0.001 A significant decrease in RET-He was seen in mild anemia (24.6 pg) and severe anemia (15.2 pg, p<0.001). RET-He was marginally reduced (p=0.0750) while serum iron and transferrin saturation were considerably lower in iron-treated subjects (p=0.0023). Reticulocyte and iron characteristics did not correlate with age (p>0.05). CONCLUSION: A sensitive, independent biomarker of iron status, RET-He measures functional iron availability during erythropoiesis. Strong correlation and severity-stratified discrimination support in populations where inflammation confounds ferritin interpretation, RET-He inclusion into iron deficient diagnostic methods. Prospective studies are needed to establish clinical thresholds and validate RET-He in chronic renal disease, inflammatory conditions, and pregnancy-related iron metabolism.

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Iron Metabolism and Disorders Hemoglobinopathies and Related Disorders Erythrocyte Function and Pathophysiology

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