The Role of Platelet-Rich Plasma (PRP) In Overcoming Repeated Implantation Failure in Art

Repeated implantation failure (RIF) remains a major challenge in assisted reproductive technologies (ART) and is often associated with impaired endometrial receptivity despite the transfer of high-quality embryos. The aim of this review is to analyze current evidence on the effectiveness of autologous platelet-rich plasma (PRP) in improving reproductive outcomes in women with RIF. A comprehensive analysis of recent literature, including randomized controlled trials, meta-analyses, and review articles, was conducted. The evaluated outcomes included implantation rate, clinical pregnancy rate, ongoing pregnancy rate, live birth rate, and endometrial thickness. PRP therapy exhibits regenerative, angiogenic, and immunomodulatory properties due to high concentrations of growth factors such as VEGF, PDGF, and TGF-β. Meta-analyses suggest that PRP use is associated with improved implantation rate (OR≈2.62), clinical pregnancy rate (OR≈2.46), and ongoing pregnancy rate (OR≈2.78). However, randomized controlled trials show inconsistent results. PRP appears to be a promising adjunctive therapy, particularly in patients with thin endometrium. Nevertheless, further large-scale randomized controlled trials are required to standardize protocols and confirm its clinical efficacy.

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