STRUCTURAL ADAPTATION AND AGE-DEPENDENT VULNERABILITY OF RAT MYOCARDIUM UNDER CARBON MONOXIDE-INDUCED HYPOXIA

Carbon monoxide exposure leads to systemic hypoxia and may cause structural myocardial injury. The aim of this study was to evaluate age-dependent morphometric changes in the myocardium of white outbred rats under carbon monoxide-induced hypoxia. The study was performed on 6- and 18-month-old white outbred rats. Myocardial tissue was examined using hematoxylin and eosin staining and digital morphometric analysis. After carbon monoxide exposure, 6-month-old rats showed moderate cardiomyocyte enlargement, reduced cellular density, increased stromal-parenchymal ratio and expansion of the pericapillary diffusion zone.

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