Impact Of Chitosan Derivatives and Heparin on Serum Homocysteine Levels and Endothelial Dysfunction in Experimental Hypercholesterolemia

Background. A strong association has been established between elevated blood homocysteine levels and increased overall mortality in patients with coronary heart disease. This study aimed to evaluate serum homocysteine levels in experimental animals with induced atherosclerosis and to determine their relationship with vascular endothelial dysfunction and different types of hyperlipoproteinemia. Methods. The experiment was conducted on 28 Chinchilla rabbits weighing 2.5–3.0 kg. The effects of the tested drugs were assessed dynamically, after three months of atherosclerosis induction and following one month of pharmacological intervention. The results were compared with control and intact groups. Results. The analysis revealed an inverse relationship between homocysteine concentration and high-density lipoprotein (HDL) cholesterol levels. Conclusion. Among the tested substances, heparin and chitosan demonstrated the most pronounced therapeutic effects, whereas gemfibrozil exhibited a comparatively weak influence.

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