EARLY STRUCTURAL AND FUNCTIONAL CHANGES OF THE MYOCARDIUM IN PATIENTS WITH METABOLIC SYNDROME: A CLINICO-MORPHOLOGICAL ANALYSIS

This study aimed to evaluate early structural and functional myocardial changes in patients with metabolic syndrome. A clinico-morphological approach was applied, including anthropometric, biochemical, and echocardiographic assessments[1,2,3]. Insulin resistance was evaluated using the HOMA-IR index. The results demonstrated early diastolic dysfunction, mitochondrial impairment, and microvascular disturbances, contributing to fibrotic changes in the myocardium. These findings highlight the importance of early diagnosis and pathogenetic treatment to prevent progression to heart failure.

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