Morphological Analysis of Changes in The Liver and Pancreas in Metabolic Syndrome in An Experimental Animal Model
Annotatsiya
Metabolic syndrome (MS) is a complex of interrelated disorders including obesity, insulin resistance, dyslipidemia, and hyperglycemia, which lead to structural and functional changes in the internal organs. Of particular importance in the pathogenesis of MS are lesions of the liver (non- alcoholic fatty liver disease, NAFLD) and pancreas (non-alcoholic fatty pancreas disease, NAFLD). This article presents an analysis of morphological changes in the hepatobiliary system and pancreatic tissue in experimental rodent models of MS. The dynamics of steatosis, inflammatory infiltration, fibrosis, and cell apoptosis depending on the duration of dietary exposure are considered. Particular attention is paid to the correlation between morphometric parameters (pancreatic islet diameter, adipocyte area, degree of fatty infiltration) and metabolic disorders (insulin resistance, hyperglycemia, dyslipidemia). The role of intestinal endotoxemia and oxidative stress in the development of organ damage is discussed.