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PATHOMORPHOLOGICAL AND IMMUNOHISTOCHEMICAL FEATURES OF CHRONIC PLACENTAL INSUFFICIENCY IN CONGENITAL INFECTIONS UNDER THE CONDITIONS OF KARAKALPAKSTAN

Sharap Iskanderovich MamutovCandidate of Medical Sciences, Department of Pathology, Karakalpakstan Medical Institute, Nukus, UzbekistanAzizbek Amangalievich AtazhanovMaster's Student of Pathological Anatomy, Karakalpakstan Medical Institute, Nukus, UzbekistanZiyuar Khojabay qizi AlauatdinovaMaster's Student of Pathological Anatomy, Tashkent Medical Academy, Tashkent, Uzbekistan

Zenodo (CERN European Organization for Nuclear Research)repository2026en

ABI

Annotatsiya

Chronic placental insufficiency (CPI) remains a critical obstetric complication, serving as a primary vector for intrauterine growth restriction, preterm birth, and perinatal mortality. In regions experiencing severe ecological degradation, such as the Republic of Karakalpakstan in the Aral Sea disaster zone, the etiology of CPI is profoundly compounded by environmental toxicity, high regional rates of maternal anemia, and the prevalent transmission of congenital (TORCH) infections. This comprehensive report investigates the synergistic impact of environmental factors and infectious agents on the pathomorphological and immunohistochemical (IHC) architecture of the human placenta. Utilizing advanced digital histomorphometry and computational image analysis, the study quantifies key biomarkers associated with angiogenesis (VEGF), cellular proliferation (Ki-67), apoptosis (Caspase-3), and localized inflammatory responses (CD68).

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Mavzular

Pregnancy and preeclampsia studies Maternal and fetal healthcare Reproductive System and Pregnancy

Identifikatorlar

DOI: 10.5281/zenodo.20289692

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