Study Of the Effect of New Phytin Compounds In Experimental Hepatitis

Alcoholic liver disease (ALD) remains one of the leading causes of chronic liver pathology worldwide and includes fatty degeneration, alcoholic hepatitis, and liver cirrhosis. The present study aimed to evaluate the hepatoprotective activity of the drug Fitin-S in an experimental model of alcoholic hepatitis induced by ethanol administration against the background of toxic liver injury caused by carbon tetrachloride (CCl4). Experimental alcoholic hepatitis was modeled in rats by preliminary administration of 50% CCl4 solution followed by intragastric administration of increasing doses of ethanol. After induction of liver injury, animals received hepatoprotective therapy with Essentiale (20 mg/kg) and Fitin-S at doses of 20 mg/kg and 50 mg/kg for 10 days. Biochemical and histopathological parameters were assessed using standard laboratory methods. The experimental model resulted in significant hepatocellular and cholestatic liver damage characterized by elevated ALT, AST, alkaline phosphatase, bilirubin, prolonged prothrombin time, decreased total protein levels, and severe fatty degeneration of hepatocytes. Treatment with Fitin-S significantly reduced cytolysis and cholestasis markers, improved protein-synthesizing and detoxification functions of the liver, normalized prothrombin time, and decreased the severity of fatty liver degeneration. The most pronounced therapeutic effect was observed at a dose of 20 mg/kg, demonstrating efficacy comparable to the reference hepatoprotector Essentiale. Histological findings confirmed the biochemical results, indicating substantial restoration of liver structure and function. The obtained data suggest that Fitin-S possesses significant hepatoprotective activity and may be considered a promising agent for the correction of alcoholic liver injury of mixed hepatocellular-cholestatic type.

Hali tarjima qilinmagan