Methodological concerns in the association between gut microbiota and sarcopenia: from cross‑sectional associations to statistical fragility
Sharipova GulniholDepartment of Hygiene, No 2 of the Bukhara state medical institute named after Abu Ali Ibn Sino, Bukhara, UzbekistanNurullaev AbdukhamidFaculty of Physical Culture Bukhara State Pedagogical Institute, Piridastgir street, 2nd house, Bukhara, UzbekistanTurakulov RustamDepartment of internal medicine in family medicine, Tashkent State Medical University, Tashkent, UzbekistanUlmasov FirdavsDepartment of Oncology, Samarkand State Medical University, Samarkand, UzbekistanArman Abroumand GholamiDepartment of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. [email protected]
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This commentary critically appraises the cross‑sectional study by Nasrollahizadeh et al. on gut microbiota and sarcopenia in Iranian older adults. Key limitations include; after FDR correction for twelve bacterial genera, no significant differences remained between groups; Akkermansia lost significance in sensitivity analyses; Lactobacillus showed a confidence interval including 1.00; four primer pairs lacked validation with no MIQE‑compliant efficiency data; the cross‑sectional design precludes causal inference; and no sample size justification was reported. The study offers valuable hypothesis‑generating data, but evidence remains preliminary. Future longitudinal studies with metagenomic approaches are essential.
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