CLINICAL, BIOCHEMICAL, AND HORMONAL ASPECTS OF METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE (MASLD) IN WOMEN

This article comprehensively examines the clinical, biochemical, and hormonal aspects of metabolic dysfunction-associated steatotic liver disease (MASLD) in women. The relevance of the study lies in the fact that in recent years, this disease has gained global significance as a core component of the metabolic syndrome and develops in close correlation with hormonal fluctuations, particularly within the female body. The article scientifically analyzes the roles of insulin resistance, lipid metabolism disorders, oxidative stress, and inflammatory processes in the pathogenesis of MASLD. During the study, alongside clinical symptoms such as general weakness, dyspeptic signs, and pain in the right hypochondrium, the latent (asymptomatic) course of the disease was specifically highlighted in female patients. Liver enzymes (ALT, AST), lipid profile, glucose levels, and markers of insulin resistance were evaluated as biochemical indicators, revealing a direct correlation with the severity of the disease. Furthermore, hormonal imbalances, specifically fluctuations in estrogen, progesterone, and thyroid hormones, were substantiated as crucial factors in the development of MASLD in women. The article provides a comparative analysis of the disease progression between women of reproductive age and those in menopause. Notably, it was determined that the decline in estrogen levels during menopause accelerates fat accumulation in liver tissues, leading to a more severe course of the disease. Based on the findings, the study emphasizes the necessity of a comprehensive diagnostic approach—combining clinical, laboratory, and hormonal assessments—for the early detection of MASLD. In conclusion, it is noted that an individual approach, encouraging a healthy lifestyle, rational nutrition, increasing physical activity, and monitoring hormonal balance play a pivotal role in the prevention and management of MASLD in women. The results of this study serve as a scientific and practical foundation for early diagnosis, prognosis, and the development of effective treatment strategies for the disease.

Hali tarjima qilinmagan