THE SIGNIFICANCE OF MOLECULAR-GENETIC MARKERS IN THE PATHOGENESIS OF MISCARRIAGE

Miscarriage remains one of the most pressing challenges in modern obstetric and gynecological practice and is considered a significant factor contributing to the decline of women's reproductive potential. Despite the introduction of advanced prenatal screening methods and improvements in the management of early gestation, the incidence of spontaneous abortion remains consistently high. According to various studies, early reproductive losses account for a substantial proportion of clinically confirmed pregnancies. Disturbances in the expression of genes regulating angiogenesis, apoptosis, and immune tolerance play a crucial role in the pathogenesis of miscarriage. Pathological alterations of the endometrium and reduced endometrial receptivity lead to impaired implantation processes. A comprehensive analysis of pathogenic mechanisms makes it possible to identify individual risk factors more accurately. In-depth investigation of molecular markers opens new perspectives for personalized prevention and management strategies aimed at reducing reproductive losses.

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