NEUROPHYSIOLOGICAL AND BIOCHEMICAL CRITERIA IN THE DIAGNOSIS OF PROGRESSIVE MUSCULAR DYSTROPHIES

A comprehensive clinical examination, electroneuromyography (ENMG), electromyography (EMG), biochemical tests (creatine kinase, lactate dehydrogenase, aminotransferases, troponin I), and inflammatory markers (interleukins, TNF-) were performed in 25 patients with progressive muscular dystrophy.Creatine kinase levels were elevated in all patients, averaging 28401650 U/L.The highest values (42501980 U/L) were observed in patients with Duchenne muscular dystrophy.Electromyographic studies revealed myopathic changes in all patients: the PDE amplitude was 485180 V, the duration was 7.22.1 ms, and the polyphasic nature was 28.48.6%.Elevated troponin I levels were detected in 8 patients (32%).Most patients had elevated inflammatory markers (IL-1, IL-6, TNF-).Comprehensive diagnostics are highly effective in identifying PMD, increasing diagnostic accuracy to 92% and improving differential diagnosis of various forms of the disease.

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