A High-Coverage Genome Sequence from an Archaic Denisovan Individual
Matthias MeyerDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, GermanyMartin KircherDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, GermanyMarie-Theres GansaugeDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, GermanyHeng LiBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USAFernando RacimoDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, GermanySwapan MallickBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USAJoshua G. SchraiberDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USAFlora JayDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USAKay PrüferDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, GermanyCesare de FilippoDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, GermanyPeter H. SudmantDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USACan AlkanDepartment of Computer Engineering, Bilkent University, 06800 Ankara, TurkeyQiaomei FuCAS-MPS Joint Laboratory for Human Evolution, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, 100044 Beijing, ChinaRon DoBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USANadin RohlandBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USAArti TandonBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USAMichael SiebauerDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, GermanyRichard E. GreenJack Baskin School of Engineering, University of California, Santa Cruz, Santa Cruz, CA 95064, USAKatarzyna BrycDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USAAdrian W. BriggsDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USAUdo StenzelDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, GermanyJesse DabneyDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, GermanyJay ShendureDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USAJacob O. KitzmanDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USAMichael F. HammerArizona Research Laboratories, Division of Biotechnology, University of Arizona, Tucson, AZ 85721, USAM.V. ShunkovPalaeolithic Department, Institute of Archaeology and Ethnography, Russian Academy of Sciences, Siberian Branch, 630090 Novosibirsk, RussiaА. П. ДеревянкоPalaeolithic Department, Institute of Archaeology and Ethnography, Russian Academy of Sciences, Siberian Branch, 630090 Novosibirsk, RussiaNick PattersonBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USAAida M. AndrésDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, GermanyEvan E. EichlerDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USAMontgomery SlatkinDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USADavid ReichBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USAJanet KelsoDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, GermanySvante PääboDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany
2012en
ABI
Annotatsiya
We present a DNA library preparation method that has allowed us to reconstruct a high-coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality of this genome allows a direct estimation of Denisovan heterozygosity indicating that genetic diversity in these archaic hominins was extremely low. It also allows tentative dating of the specimen on the basis of "missing evolution" in its genome, detailed measurements of Denisovan and Neandertal admixture into present-day human populations, and the generation of a near-complete catalog of genetic changes that swept to high frequency in modern humans since their divergence from Denisovans.
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