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Atomic scale understanding of the permeation of plasma species across native and oxidized membranes

Jamoliddin RazzokovResearch Group PLASMANT, Department of Chemistry, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, BelgiumMaksudbek YusupovResearch Group PLASMANT, Department of Chemistry, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, BelgiumRodrigo M. CordeiroCentro de Ciências Naturais e Humanas, Universidade Federal do ABC, Avenida dos Estados 5001, CEP 09210-580, Santo André, SP, BrazilAnnemie BogaertsResearch Group PLASMANT, Department of Chemistry, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium

2018en

ABI

Annotatsiya

Abstract Cold atmospheric plasmas (CAPs) have attracted significant interest for their potential benefits in medical applications, including cancer therapy. The therapeutic effects of CAPs are related to reactive oxygen and nitrogen species (ROS and RNS) present in the plasma. The impact of ROS has been extensively studied, but the role of RNS in CAP-treatment remains poorly understood at the molecular level. Here, we investigate the permeation of RNS and ROS across native and oxidized phospholipid bilayers (PLBs) by means of computer simulations. The results reveal significantly lower free energy barriers for RNS (i.e. NO, NO 2 , N 2 O 4 ) and O 3 compared to hydrophilic ROS, such as OH, HO 2 and H 2 O 2 . This suggests that the investigated RNS and O 3 can permeate more easily through both native and oxidized PLBs in comparison to hydrophilic ROS, indicating their potentially important role in plasma medicine.

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DOI: 10.1088/1361-6463/aad524

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