Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology
J D van EmbdenUnit Molecular Microbiology, National Institute of Public Health and Environmental Protection, Bilthoven, The NetherlandsM. Donald CaveUnit Molecular Microbiology, National Institute of Public Health and Environmental Protection, Bilthoven, The NetherlandsJack T. CrawfordUnit Molecular Microbiology, National Institute of Public Health and Environmental Protection, Bilthoven, The NetherlandsJeremy W. DaleUnit Molecular Microbiology, National Institute of Public Health and Environmental Protection, Bilthoven, The NetherlandsKathleen D. EisenachUnit Molecular Microbiology, National Institute of Public Health and Environmental Protection, Bilthoven, The NetherlandsBrigitte GicquelUnit Molecular Microbiology, National Institute of Public Health and Environmental Protection, Bilthoven, The NetherlandsPeter W. M. HermansUnit Molecular Microbiology, National Institute of Public Health and Environmental Protection, Bilthoven, The NetherlandsCarlos Martı́nUnit Molecular Microbiology, National Institute of Public Health and Environmental Protection, Bilthoven, The NetherlandsRuth A. McAdamUnit Molecular Microbiology, National Institute of Public Health and Environmental Protection, Bilthoven, The NetherlandsThomas M. ShinnickUnit Molecular Microbiology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands
1993en
ABI
Annotatsiya
DNA fingerprinting of Mycobacterium tuberculosis has been shown to be a powerful epidemiologic tool. We propose a standardized technique which exploits variability in both the number and genomic position of IS6110 to generate strain-specific patterns. General use of this technique will permit comparison of results between different laboratories. Such comparisons will facilitate investigations into the international transmission of tuberculosis and may identify specific strains with unique properties such as high infectivity, virulence, or drug resistance.
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