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The Science of Resilience: Implications for the Prevention and Treatment of Depression

Steven M. SouthwickYale University School of Medicine and Yale Child Study Center, U.S. Department of Veterans Affairs (VA) National Center for Post-Traumatic Stress Disorder, VA Connecticut Healthcare System, 950 Campbell Avenue 116A, West Haven, CT 06516, USADennis S. CharneyMount Sinai School of Medicine, The Mount Sinai Medical Center, Department of Psychiatry, Department of Neuroscience, and Department of Pharmacology and Systems Therapeutics, One Gustave L. Levy Place, Box 1217, New York, NY 10029, USA
2012en
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Human responses to stress and trauma vary widely. Some people develop trauma-related psychological disorders, such as posttraumatic stress disorder (PTSD) and depression; others develop mild to moderate psychological symptoms that resolve rapidly; still others report no new psychological symptoms in response to traumatic stress. Individual variability in how animals and humans respond to stress and trauma depends on numerous genetic, developmental, cognitive, psychological, and neurobiological risk and protective factors.

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