Bright Fluorescent Nanodiamonds: No Photobleaching and Low Cytotoxicity
Amy S. YuInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan 106, Genomics Research Center, Taipei, Taiwan 115, and Institute of Physics, Academia Sinica, Taipei, Taiwan 115, R.O.CMing‐Wei KangInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan 106, Genomics Research Center, Taipei, Taiwan 115, and Institute of Physics, Academia Sinica, Taipei, Taiwan 115, R.O.CHuan‐Cheng ChangInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan 106, Genomics Research Center, Taipei, Taiwan 115, and Institute of Physics, Academia Sinica, Taipei, Taiwan 115, R.O.CKuan-Ming ChenInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan 106, Genomics Research Center, Taipei, Taiwan 115, and Institute of Physics, Academia Sinica, Taipei, Taiwan 115, R.O.CYueh‐Chung YuInstitute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan 106, Genomics Research Center, Taipei, Taiwan 115, and Institute of Physics, Academia Sinica, Taipei, Taiwan 115, R.O.C
2005en
ABI
Annotatsiya
Diamond nanocrystals emit bright fluorescence at 600-800 nm after irradiation by a 3 MeV proton beam (5 x 1015 ions/cm2) and annealing at 800 degrees C (2 h) in vacuum. The irradiation/annealing process yields high concentrations of nitrogen-vacancy defect centers ( approximately 107 centers/mum3), making possible visualization of the individual 100 nm diamond crystallites using a fluorescence microscope. The fluorescent nanodiamonds (FND) show no sign of photobleaching and can be taken up by mammalian cells with minimal cytotoxicity. The nanomaterial can have far-reaching biological applications.
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