Maqola

Multilineage Potential of Adult Human Mesenchymal Stem Cells

Mark F. PittengerOsiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231–3043, USAAlastair M. MackayOsiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231–3043, USAStephen C. BeckOsiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231–3043, USARama K. JaiswalOsiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231–3043, USAR. Gordon DouglasOsiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231–3043, USAJoseph D. MoscaOsiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231–3043, USAMark A. MoormanOsiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231–3043, USADonald W. SimonettiOsiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231–3043, USAStewart CraigOsiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231–3043, USADaniel R. MarshakJohns Hopkins University, School of Medicine, Baltimore, MD 21205, USA

1999en

ABI

Annotatsiya

Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tendon, muscle, and marrow stroma. Cells that have the characteristics of human mesenchymal stem cells were isolated from marrow aspirates of volunteer donors. These cells displayed a stable phenotype and remained as a monolayer in vitro. These adult stem cells could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages. Individual stem cells were identified that, when expanded to colonies, retained their multilineage potential.

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Identifikatorlar

DOI: 10.1126/science.284.5411.143

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