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Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor

Youyong YuanHefei National Laboratory for Physical, Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P.R. ChinaChengqiong MaoHefei National Laboratory for Physical, Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P.R. China,Xiao‐Jiao DuHefei National Laboratory for Physical, Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P.R. China,Jin‐Zhi DuCAS Key Laboratory of Soft Matter Chemistry and Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P.R. ChinaFeng WangHefei National Laboratory for Physical, Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P.R. China,Jun WangHefei National Laboratory for Physical, Sciences at Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P.R. China,

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Annotatsiya

Two faced nanoparticles: A zwitterionic polymer-based nanoparticle with response to tumor acidity is developed for enhanced drug delivery to tumors. The nanoparticles are neutrally charged at physiological conditions and show prolonged circulation time; after leaking into tumor sites, in the acidic extracellular tumor environment (pHe), nanoparticles are activated and become positively charged and are therefore efficiently taken up by tumor cells, leading to enhanced therapeutic effects in cancer treatment. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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Identifikatorlar

DOI: 10.1002/adma.201202296

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