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Role of microbiota-derived short-chain fatty acids in cancer development and prevention

Rasoul MirzaeiDepartment of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Venom and Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran. Electronic address: [email protected]Azam AfaghiDepartment of Biology, Sofian Branch, Islamic Azad University, Sofian, IranSajad BabakhaniDepartment of Microbiology, North Tehran Branch, Islamic Azad University, Tehran, IranMasoudreza SohrabiGastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, IranSeyed Reza Hosseini‐FardDepartment of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, IranKiandokht BabolhavaejiDepartment of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IranShabnam Khani Ali AkbariDepartment of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IranRasoul YousefimashoufDepartment of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: [email protected]Sajad KarampoorGastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected]

2021en

ABI

Annotatsiya

Following cancer, cells in a particular tissue can no longer respond to the factors involved in controlling cell survival, differentiation, proliferation, and death. In recent years, it has been indicated that alterations in the gut microbiota components, intestinal epithelium, and host immune system are associated with cancer incidence. Also, it has been demonstrated that the short-chain fatty acids (SCFAs) generated by gut microbiota are vitally crucial in cell homeostasis as they contribute to the modulation of histone deacetylases (HDACs), resulting effected cell attachment, immune cell immigration, cytokine production, chemotaxis, and the programmed cell death. Therefore, the manipulation of SCFA levels in the intestinal tract by alterations in the microbiota structure can be potentially taken into consideration for cancer treatment/prevention. In the current study, we will explain the most recent findings on the detrimental or protective roles of SFCA (particularly butyrate, propionate, and acetate) in several cancers, including bladder, colon, breast, stomach, liver, lung, pancreas, and prostate cancers.

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DOI: 10.1016/j.biopha.2021.111619

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