Sharh maqola

The regulatory role of autophagy-related miRNAs in lung cancer drug resistance

Mahshid ShahverdiMedical Biotechnology Research Center, Arak University of Medical Sciences, Arak, IranKhalil HajiasgharzadehImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranAmin Daei SorkhabiStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, IranMahdi JafarlouImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranMaryam ShojaeeDepartment of Clinical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranNeda Jalili TabriziImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranNazila AlizadehImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, IranMariacarmela SantarpíaMedical Oncology Unit, Department of Human Pathology "G. Barresi", University of Messina, Messina, ItalyOronzo BrunettiMedical oncology unit, IRCCS Istituto Tumori "Giovanni Paolo II" of Bari, Bari, ItalyHossein SafarpourCellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, IranNicola SilvestrisMedical oncology unit, IRCCS Istituto Tumori "Giovanni Paolo II" of Bari, Bari, Italy; Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari, Bari, Italy. Electronic address: [email protected]Behzad BaradaranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: [email protected]

2022en

ABI

Annotatsiya

Autophagy is conserved cellular machinery that degrades un-usable proteins and cellular components and has a crucial role in the pathogenesis and drug resistance of various diseases such as lung cancer (LC). Multiple types of endogenous molecules (i.e. miRNAs) have been found to regulate multiple biological processes, such as autophagy. Dysfunction of these molecules is associated with the onset and progression of a variety of human malignancies. Several studies had shown that some miRNAs could mediate autophagy activity in LC cells, which would affect drug resistance as a major problem in LC therapy. Therefore, identifying the underlying molecular targets of miRNAs and their function in autophagy pathways could develop new treatment interventions for LC patients. In this review, we will summarize the interplay between miRNAs, autophagy, and drug resistance of LC patients, as well as the genes and molecular pathways that are involved.

Hali tarjima qilinmagan

Identifikatorlar

DOI: 10.1016/j.biopha.2022.112735

Iqtiboslar va manbalar

2 ta iqtibos0 ta foydalanilgan manba

Koʻrsatkichlar — AkademScholar