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<i>In Vitro</i>Antimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin

Dayanne Rakelly de OliveiraPrograma de Pós-Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria, 97105-700 Santa Maria, RS, BrazilSaulo Relison TintinoLaboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri (URCA), 63100-000 Crato, CE, BrazilMaria Flaviana Bezerra Morais‐BragaLaboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri (URCA), 63100-000 Crato, CE, BrazilAline Augusti BoligonDepartamento de Farmácia Industrial, Universidade Federal de Santa Maria, 97105-700 Santa Maria, RS, BrazilMargareth Linde AthaydeDepartamento de Farmácia Industrial, Universidade Federal de Santa Maria, 97105-700 Santa Maria, RS, BrazilHenrique Douglas Melo CoutinhoLaboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri (URCA), 63100-000 Crato, CE, BrazilIrwin Rose Alencar de MenezesLaboratório de Microbiologia e Biologia Molecular, Departamento de Química Biológica, Universidade Regional do Cariri, 63100-000 Crato,CE, BrazilRoselei FachinettoPrograma de Pós-Graduação em Ciências Biológicas, Bioquímica Toxicológica, Universidade Federal de Santa Maria, 97105-700 Santa Maria, RS, Brazil

2015en

ABI

Annotatsiya

Silymarin is a standardized extract from the dried seeds of the milk thistle (Silybum marianum L. Gaertn.) clinically used as an antihepatotoxic agent. The aim of this study was to investigate the antibacterial and antifungal activity of silymarin and its major constituent (silibinin) against different microbial strains and their modulatory effect on drugs utilized in clinical practice. Silymarin demonstrated antimicrobial activity of little significance against the bacterial strains tested, with MIC (minimum inhibitory concentration) values of 512 µg/mL. Meanwhile, silibinin showed significant activity against Escherichia coli with a MIC of 64 µg/mL. The results for the antifungal activity of silymarin and silibinin demonstrated a MIC of 1024 µg/mL for all strains. Silymarin and silibinin appear to have promising potential, showing synergistic properties when combined with antibacterial drugs, which should prompt further studies along this line.

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DOI: 10.1155/2015/292797

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