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The cardioprotective effects of nano‐curcumin against doxorubicin‐induced cardiotoxicity: A systematic review

Hossein MoutabianRadiation Sciences Research Center (RSRC) AJA University of Medical Sciences Tehran IranRuhollah Ghahramani‐AslDepartment of Medical Physics and Radiological Sciences Faculty of Paramedicine, Sabzevar University of Medical Sciences Sabzevar IranTohid MortezazadehDepartment of Medical Physics School of Medicine, Tabriz University of Medical Science Tabriz IranReza LaripourRadiation Sciences Research Center (RSRC) AJA University of Medical Sciences Tehran IranAsghar NarmaniDepartment of Life Science Engineering Faculty of New Sciences and Technologies, University of Tehran Tehran IranHamed ZamaniDepartment of Medical Physics School of Medicine, Shahid Sadoughi University of Medical Sciences Yazd IranGholamreza AtaeiDepartment of Radiology Technology Faculty of Paramedical Sciences, Babol University of Medical Sciences Babol IranHamed BagheriRadiation Biology Research Center Iran University of Medical Sciences Tehran IranBagher FarhoodDepartment of Medical Physics and Radiology Faculty of Paramedical Sciences, Kashan University of Medical Sciences Kashan IranThozhukat SathyapalanAcademic Diabetes, Endocrinology and Metabolism Hull York Medical School (HYMS), The University of Hull Hull UKAmirhossein SahebkarApplied Biomedical Research Center Mashhad University of Medical Sciences, Pharmaceutical Technology Institute Mashhad Iran

2022en

ABI

Annotatsiya

Although the chemotherapeutic drug, doxorubicin, is commonly used to treat various malignant tumors, its clinical use is restricted because of its toxicity especially cardiotoxicity. The use of curcumin may alleviate some of the doxorubicin-induced cardiotoxic effects. Especially, using the nano-formulation of curcumin can overcome the poor bioavailability of curcumin and enhance its physicochemical properties regarding its efficacy. In this study, we systematically reviewed the potential cardioprotective effects of nano-curcumin against the doxorubicin-induced cardiotoxicity. A systematic search was accomplished based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for the identification of all relevant articles on "the role of nano-curcumin on doxorubicin-induced cardiotoxicity" in the electronic databases of Scopus, PubMed, and Web of Science up to July 2021. One hundred and sixty-nine articles were screened following a predefined set of inclusion and exclusion criteria. Ten eligible scientific papers were finally included in the present systematic review. The administration of doxorubicin reduced the body and heart weights of mice/rats compared to the control groups. In contrast, the combined treatment of doxorubicin and nano-curcumin increased the body and heart weights of animals compared with the doxorubicin-treated groups alone. Furthermore, doxorubicin could significantly induce the biochemical and histological changes in the cardiac tissue; however, coadministration of nano-curcumin formulation demonstrated a pattern opposite to the doxorubicin-induced changes. The coadministration of nano-curcumin alleviates the doxorubicin-induced cardiotoxicity through various mechanisms including antioxidant, anti-inflammatory, and antiapoptotic effects. Also, the cardioprotective effect of nano-curcumin formulation against doxorubicin-induced cardiotoxicity was higher than free curcumin.

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DOI: 10.1002/biof.1823

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