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The Effect of Silver Nanoparticles on Antioxidant/Pro-Oxidant Balance in a Murine Model

Anca Oana DoceaDepartment of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDaniela CălinaDepartment of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaAna Maria BugăDepartment of Biochemistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaOvidiu ZlatianDepartment of Microbiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaMônica Maria Bastos PaolielloDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Forchheimer 209,1300 Morris Park Avenue, Bronx, NY 10461, USAGeorge Dan MogoşanuDepartment of Pharmacognosy and Phytotherapy, Faculty of Pharmacy University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaCostin Teodor StrebaDepartment of Research Methodology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaElena Leocadia PopescuDoctoral School University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaAlexandra Elena StoicaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, RomaniaAlexandra Cătălina BîrcăDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, RomaniaBogdan Ştefan VasileDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, RomaniaAlexandru Mihai GrumezescuDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, RomaniaLaurenţiu MogoantăDepartment of Histology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania

2020en

ABI

Annotatsiya

This study aimed to evaluate the subacute effect of two types of Ag-NPs(EG-AgNPs and PVP-EG-AgNPs) on antioxidant/pro-oxidant balance in rats. Seventy Wistar rats (35 males and 35 females) were divided in 7 groups and intraperitoneally exposed for 28 days to 0, 1, 2 and 4 mg/kg bw/day EG-Ag-NPs and 1, 2 and 4 mg/kg bw/day PVP- EG-Ag-NPs. After 28 days, the blood was collected, and the total antioxidant capacity (TAC), thiobarbituric reactive species (TBARS),protein carbonyl (PROTC) levels, reduced glutathione (GSH) levels and catalase (CAT) activity were determined. EG-Ag-NPs determined protective antioxidant effects in a dose-dependent manner. The exposure to the 4 mg/kg bw/day EG-Ag-NPs determines both in males and females a significant increase in TAC and CAT and a significant decrease in TBARS and PROTC only in females. The PVP-EG-AgNPs showed a different trend compared to EG-AgNPs. At 4 mg/kg bw/day the PVP-EG-AgNPs induce increased PROTC levels and decreased GSH (males and females) and TAC levels (males). The different mechanisms of EG-AgNPs and PVP-EG-AgNPs on antioxidant-/pro-oxidant balance can be explained by the influence of coating agent used for the preparation of the nanoparticles in the formation and composition of protein corona that influence their pathophysiology in the organism.

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DOI: 10.3390/ijms21041233

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