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Iron Oxide Nanoparticles for Magnetically-Guided and Magnetically-Responsive Drug Delivery

Joan EstelrichDepartament de Fisicoquímica; Facultat de Farmàcia; Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, SpainElvira EscribanoDepartament de Farmàcia i Tecnologia Farmacèutica, Facultat de Farmàcia, Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, SpainJosep QueraltDepartament de Fisiologia, Facultat de Farmàcia; Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, SpainMaria Antònia BusquetsDepartament de Fisicoquímica; Facultat de Farmàcia; Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain

2015en

ABI

Annotatsiya

In this review, we discuss the recent advances in and problems with the use of magnetically-guided and magnetically-responsive nanoparticles in drug delivery and magnetofection. In magnetically-guided nanoparticles, a constant external magnetic field is used to transport magnetic nanoparticles loaded with drugs to a specific site within the body or to increase the transfection capacity. Magnetofection is the delivery of nucleic acids under the influence of a magnetic field acting on nucleic acid vectors that are associated with magnetic nanoparticles. In magnetically-responsive nanoparticles, magnetic nanoparticles are encapsulated or embedded in a larger colloidal structure that carries a drug. In this last case, an alternating magnetic field can modify the structure of the colloid, thereby providing spatial and temporal control over drug release.

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DOI: 10.3390/ijms16048070

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