Maqola

Mitochondria-targeted antioxidants as highly effective antibiotics

Pavel A. NazarovBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia. [email protected]Ilya А. OstermanDepartment of Chemistry, Lomonosov Moscow State University, Moscow, 119991, RussiaA. V. TokarchukBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, RussiaMarina V. KarakozovaVavilov Institute of General Genetics, Russian Academy of Science, Moscow, 117971, RussiaGalina A. KorshunovaBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, RussiaKonstantin G. LyamzaevBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, RussiaMaxim V. SkulachevBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, RussiaЕlena А. KotovaBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, RussiaVladimir P. SkulachevBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, RussiaYuri N. AntonenkoBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia

2017en

ABI

Annotatsiya

Mitochondria-targeted antioxidants are known to alleviate mitochondrial oxidative damage that is associated with a variety of diseases. Here, we showed that SkQ1, a decyltriphenyl phosphonium cation conjugated to a quinone moiety, exhibited strong antibacterial activity towards Gram-positive Bacillus subtilis, Mycobacterium sp. and Staphylococcus aureus and Gram-negative Photobacterium phosphoreum and Rhodobacter sphaeroides in submicromolar and micromolar concentrations. SkQ1 exhibited less antibiotic activity towards Escherichia coli due to the presence of the highly effective multidrug resistance pump AcrAB-TolC. E. coli mutants lacking AcrAB-TolC showed similar SkQ1 sensitivity, as B. subtilis. Lowering of the bacterial membrane potential by SkQ1 might be involved in the mechanism of its bactericidal action. No significant cytotoxic effect on mammalian cells was observed at bacteriotoxic concentrations of SkQ1. Therefore, SkQ1 may be effective in protection of the infected mammals by killing invading bacteria.

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Identifikatorlar

DOI: 10.1038/s41598-017-00802-8

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