Changes in lipids composition and metabolism in colorectal cancer: a review
Alicja PakietDepartment of Environmental Analysis, Faculty of Chemistry, University of Gdansk, Gdansk, PolandJarek KobielaDepartment of General, Endocrine and Transplant Surgery, Faculty of Medicine, Medical University of Gdansk, Gdansk, PolandPiotr StepnowskiDepartment of Environmental Analysis, Faculty of Chemistry, University of Gdansk, Gdansk, PolandTomasz ŚledzińskiDepartment of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdansk, Dębinki 1, 80-211, Gdansk, Poland. [email protected]Adriana MikaDepartment of Environmental Analysis, Faculty of Chemistry, University of Gdansk, Gdansk, Poland
2019en
ABI
Annotatsiya
Altered metabolism of lipids is currently considered a hallmark characteristic of many malignancies, including colorectal cancer (CRC). Lipids are a large group of metabolites that differ in terms of their fatty acid composition. This review summarizes recent evidence, documenting many alterations in the content and composition of fatty acids, polar lipids, oxylipins and triacylglycerols in CRC patients' sera, tumor tissues and adipose tissue. Some of altered lipid molecules may be potential biomarkers of CRC risk, development and progression. Owing to a significant role of many lipids in cancer cell metabolism, some of lipid metabolism pathways may also constitute specific targets for anti-CRC therapy.
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