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Quorum Quenching: Role of Nanoparticles as Signal Jammers in Gram-Negative Bacteria

Sumreen HayatDepartment of Biotechnology,University of Sargodha, University Road, Sargodha 40100, PakistanSaima MuzammilDepartment of Microbiology,Government College University, Faisalabad, PakistanShabana ShabanaDepartment of Microbiology & Molecular Genetics,Quaid-e-Azam Campus,University of the Punjab, Lahore, PakistanBilal AslamDepartment of Microbiology,Government College University, Faisalabad, PakistanMuhammad Hussnain SiddiqueDepartment of Bioinformatics & Biotechnology,Government College University, Faisalabad, PakistanMuhammad SaqaleinDepartment of Microbiology,Government College University, Faisalabad, PakistanMuhammad Atif NisarDepartment of Microbiology,Government College University, Faisalabad, Pakistan

2018en

ABI

Annotatsiya

Quorum sensing (QS) is a cell density dependent regulatory process that uses signaling molecules to manage the expression of virulence genes and biofilm formation. The study of QS inhibitors has emerged as one of the most fascinating areas of research to discover novel antimicrobial agents. Compounds that block QS have become candidates as unusual antimicrobial agents, as they are leading players in the regulation of virulence of drug-resistant pathogens. Metal and metal oxide nanoparticles offer novel alternatives to combat antibiotic resistance in Gram-negative bacteria aiming their capacity as QS inhibitors. This review provides an insight into the quorum quenching potential of metal and metal oxide nanoparticles by targeting QS regulated virulence of Gram-negative bacteria.

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DOI: 10.2217/fmb-2018-0257

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