Are Natural Deep Eutectic Solvents the Missing Link in Understanding Cellular Metabolism and Physiology?
Young Hae ChoiNatural Products Laboratory, Institute of Biology (Y.H.C., Y.D., M.V., R.V.), Leiden University, 2300 RA Leiden, The Netherlands; and Laboratory for Process Equipment (Y.H.C., J.v.S., G.-J.W.) and Biocatalysis and Organic Chemistry Group, Department of Biotechnology (F.H., I.W.C.E.A.), Delft University of Technology, 2628 CA Delft, The NetherlandsJaap van SpronsenNatural Products Laboratory, Institute of Biology (Y.H.C., Y.D., M.V., R.V.), Leiden University, 2300 RA Leiden, The Netherlands; and Laboratory for Process Equipment (Y.H.C., J.v.S., G.-J.W.) and Biocatalysis and Organic Chemistry Group, Department of Biotechnology (F.H., I.W.C.E.A.), Delft University of Technology, 2628 CA Delft, The NetherlandsYuntao DaiNatural Products Laboratory, Institute of Biology (Y.H.C., Y.D., M.V., R.V.), Leiden University, 2300 RA Leiden, The Netherlands; and Laboratory for Process Equipment (Y.H.C., J.v.S., G.-J.W.) and Biocatalysis and Organic Chemistry Group, Department of Biotechnology (F.H., I.W.C.E.A.), Delft University of Technology, 2628 CA Delft, The NetherlandsMarianne C. VerberneNatural Products Laboratory, Institute of Biology (Y.H.C., Y.D., M.V., R.V.), Leiden University, 2300 RA Leiden, The Netherlands; and Laboratory for Process Equipment (Y.H.C., J.v.S., G.-J.W.) and Biocatalysis and Organic Chemistry Group, Department of Biotechnology (F.H., I.W.C.E.A.), Delft University of Technology, 2628 CA Delft, The NetherlandsFrank HollmannNatural Products Laboratory, Institute of Biology (Y.H.C., Y.D., M.V., R.V.), Leiden University, 2300 RA Leiden, The Netherlands; and Laboratory for Process Equipment (Y.H.C., J.v.S., G.-J.W.) and Biocatalysis and Organic Chemistry Group, Department of Biotechnology (F.H., I.W.C.E.A.), Delft University of Technology, 2628 CA Delft, The NetherlandsIsabel W. C. E. ArendsNatural Products Laboratory, Institute of Biology (Y.H.C., Y.D., M.V., R.V.), Leiden University, 2300 RA Leiden, The Netherlands; and Laboratory for Process Equipment (Y.H.C., J.v.S., G.-J.W.) and Biocatalysis and Organic Chemistry Group, Department of Biotechnology (F.H., I.W.C.E.A.), Delft University of Technology, 2628 CA Delft, The NetherlandsGeert‐Jan WitkampNatural Products Laboratory, Institute of Biology (Y.H.C., Y.D., M.V., R.V.), Leiden University, 2300 RA Leiden, The Netherlands; and Laboratory for Process Equipment (Y.H.C., J.v.S., G.-J.W.) and Biocatalysis and Organic Chemistry Group, Department of Biotechnology (F.H., I.W.C.E.A.), Delft University of Technology, 2628 CA Delft, The NetherlandsRobert VerpoorteNatural Products Laboratory, Institute of Biology (Y.H.C., Y.D., M.V., R.V.), Leiden University, 2300 RA Leiden, The Netherlands; and Laboratory for Process Equipment (Y.H.C., J.v.S., G.-J.W.) and Biocatalysis and Organic Chemistry Group, Department of Biotechnology (F.H., I.W.C.E.A.), Delft University of Technology, 2628 CA Delft, The Netherlands
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Over the past decade, metabolomics has developed into a major tool for studying the metabolism of organisms and cells, and through this approach much has been learned about metabolic networks and the reactions of organisms to various external conditions ([Lay et al., 2006][1]). Most of this work
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