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A comparative study of the antimicrobial and antioxidant activities of <i>Inonotus hispidus</i> fruit and their mycelia extracts

Paola AngeliniDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, ItalyCarolina Elena GiromettaDepartment of Earth and Environmental Science (DSTA), University of Pavia, Pavia, ItalyBruno TirilliniDepartment of Biomolecular Sciences, University of Urbino, Urbino, ItalySimone MorettiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, ItalyStefano CovinoDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, ItalyMelania CiprianiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, ItalyEleonora D’EllenaDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, ItalyGiancarlo Angeles FloresDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, ItalyErmanno FedericiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, ItalyElena SavinoDepartment of Earth and Environmental Science (DSTA), University of Pavia, Pavia, ItalyGabriele CrucianiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, ItalyRoberto VenanzoniDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy

2019en

ABI

Annotatsiya

Inonotus hispidus (Bull.) P. Karst. has been used as traditional medicine for the treatment of dyspepsia, cancer, and diabetes. Numerous studies have confirmed the antimicrobial, antiviral, antioxidant, anti-inflammatory, immunomodulatory, antiproliferative and cytotoxic biological activities of extracts from this species. The purpose of this study was a comparative analysis of the antioxidant and the antimicrobial activities of methanol extracts from fruit and liquid-cultured mycelia. Four compounds (N-butylbenzenesulfonamide, lauramidopropyl betaine, 3,5-di-tert-butyl-4-hydroxybenzaldehyde, and uplandicine), determined by hybrid HRMS, were found only in mycelia culture extracts. Free radical scavenging, measured by DPPH assay on methanol extracts, showed an activity of about 17.2% and 22.1% of Trolox in fruiting bodies and mycelia, respectively. The I. hispidus methanol extracts from fruit and mycelia culture were found to have varying degrees of antibacterial and antifungal effects against the pathogenic microorganisms tested (minimum inhibitory concentration from 0.17 to 2.56 μg mL−1).

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Identifikatorlar

DOI: 10.1080/10942912.2019.1609497

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