The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems
Alexandre AlbaneseInstitute of Biomaterials and Biomedical Engineering; Terrence Donnelly Center for Cellular and Biomolecular Research; Materials Science and Engineering; Chemical Engineering; and Chemistry, University of Toronto, Toronto, Ontario, Canada M5S 3G9;Peter S. TangInstitute of Biomaterials and Biomedical Engineering; Terrence Donnelly Center for Cellular and Biomolecular Research; Materials Science and Engineering; Chemical Engineering; and Chemistry, University of Toronto, Toronto, Ontario, Canada M5S 3G9;Warren C. W. ChanInstitute of Biomaterials and Biomedical Engineering; Terrence Donnelly Center for Cellular and Biomolecular Research; Materials Science and Engineering; Chemical Engineering; and Chemistry, University of Toronto, Toronto, Ontario, Canada M5S 3G9;
2012en
ABI
Annotatsiya
An understanding of the interactions between nanoparticles and biological systems is of significant interest. Studies aimed at correlating the properties of nanomaterials such as size, shape, chemical functionality, surface charge, and composition with biomolecular signaling, biological kinetics, transportation, and toxicity in both cell culture and animal experiments are under way. These fundamental studies will provide a foundation for engineering the next generation of nanoscale devices. Here, we provide rationales for these studies, review the current progress in studies of the interactions of nanomaterials with biological systems, and provide a perspective on the long-term implications of these findings.
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